Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof-of-concept clinical study.

Epilepsia · 2025 · PMC12605802 · PMID 40616775

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0700

boldest claim

The sentences

showed a trendp = .06so close (0.05 < p ≤ 0.1)

Several proinflammatory cytokines, such as Il1β, Il1α, Tnfα, Cd86, IL6, and Trem2, were significantly upregulated by SE, but no changes were induced by the CQ treatment except for Il6 and Trem2 , which showed a trend to increase ( p = .06) in CQ compared to VHC treatment (Table S1 ).

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borderline significancep = .07so close (0.05 < p ≤ 0.1)

In addition, by comparing the CQ 5‐ and 10‐mg/kg conditions, a borderline significance ( p = .07, Mann–Whitney) was observed.

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