Genotype-by-environment interactions shape ubiquitin-proteasome system activity.

Genetics · 2025 · PMC12606439 · PMID 40884183

Europe PMC DOI

hedged sentences

0.0400

closest p · 0.8× alpha

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boldest claim

The sentences

nominally significantP ≤ 0.04actually significant

For example, in LiAc, GxE was seen for all reporters in that BY showed no significant change in UPS activity compared with SC for any reporter, while RM showed at least nominally significant reductions for all reporters ( t -test for effect of environment per strain, P ≤ 0.04).

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highly significantno p-value reported

These highly significant cases of GxE illustrate how the environment can differentially shape UPS activity in genetically different individuals.

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