Improved localized mRNA delivery using lipid nanoparticles with a novel synthetic cholesterol derivative.

RSC Pharm · 2026 · PMC12606572 · PMID 41235139

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

While trending consistently with observed reduced luciferase expression, we observed decreased overall tumor weight difference in CA–caspase-3 GA–Chol LNP compared to FLuc GA–Chol LNPs; however, this comparison did not reach statistical significance ( p = 0.06) ( Fig. 7d ).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.