Evaluation of Peptide Nucleic Acid Encapsulation in Ferritin Nanocages for Gene Silencing Applications.

Notably, although the silencing efficiency observed with the ferritin-encapsulated PNA 10‐mer E4 (−) appeared higher than that achieved using the standard siRNA transfected with a conventional reagent, the difference did not reach statistical significance. 4 Conclusions In our study, we successfully demonstrated that negatively charged PNAs can be efficiently encapsulated within a polycationic protein cage known as PA3.2-HumAfFt .

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