Barely Significant
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The Impact of <i>Akkermansia muciniphila</i> on Mouse Models of Depression, Anxiety, and Stress: A Systematic Review and Meta-Analysis.

Curr Neuropharmacol · 2025 · PMC12606656 · PMID 40108902

Europe PMCDOI
2
hedged sentences
0.0500
closest p · 1.0× alpha
0.0800
boldest claim

The sentences

close to significanceP = 0.05actually significant
cAMP-responsive element-binding protein1 (CREB1), another regulator of neuronal plasticity, showed an upward trend close to significance ( P = 0.05) in the HIPP.

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did not reach statistical significanceP = 0.08so close (0.05 < p ≤ 0.1)
Similarly, the serum level of corticosterone, a stress hormone, was reduced, but the reduction did not reach statistical significance ( P = 0.08).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.