Structural and functional impact of the POLD1 Ser605del variant in MDPL syndrome: insights from protein-protein interactions.

Hum Genomics · 2025 · PMC12606881 · PMID 41219970

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a clear trendno p-value reported

Densitometric analysis of WB revealed a clear trend of increased protein levels, which was particularly evident and statistically significant only at p13 for PX (Fig. 4 B; * p < 0.05).

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a decreasing trendno p-value reported

Following X-ray irradiation, aimed at exacerbating the cellular phenotype, we observed a decreasing trend in these markers, which reached statistical significance particularly in one older patient.

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