Preparation of Lipid Cubic Liquid Crystalline Nanoparticles of Sinomenine Based on Molecular Dynamics Simulations and Investigation of the Efficacy Against Rheumatoid Arthritis.

ANOVA indicated that the model was highly significant ( p < 0.0001) with an insignificant lack of fit ( p = 0.3319 > 0.05), demonstrating good overall fitness.

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In terms of anti-inflammatory efficacy, the Dex group showed a trend towards superiority compared with the SIN-LCNP group; however, statistical analysis revealed no significant differences between the two groups ( p > 0.05).

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