A Celsr3 Mutation Linked to Tourette Disorder Disrupts Cortical Dendritic Patterning and Striatal Cholinergic Interneuron Excitability.

Int J Mol Sci · 2025 · PMC12610430 · PMID 41226347

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.1250

boldest claim

The sentences

a strong trendp = 0.055so close (0.05 < p ≤ 0.1)

There was also a significant reduction in stubby spines in Celsr3 R774H/R774H animals ( p = 0.033), and a strong trend toward an increase in long thin spines ( p = 0.055, multiple t -tests corrected for multiple comparisons).

also in 5,725 other papers

failed to reach significancep = 0.125not close (p > 0.1)

By comparison, in a Celsr3 eGFP/+ reporter mouse, we observed less colocalization between GFP expressing cells and PV+ interneurons, although their difference failed to reach significance ( Supplementary Figure S1c,d , Wilcoxon signed-rank test, one-tailed, median difference between ChAT-PV: 0.33, p = 0.125).

also in 4,113 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.