Systematic Assessment of Matrix Effect, Recovery, and Process Efficiency Using Three Complementary Approaches: Implications for LC-MS/MS Bioanalysis Applied to Glucosylceramides in Human Cerebrospinal Fluid.

Considering these conditions, the LoQ of our method was set at 5 nM based on precision and accuracy criteria. The scatter plots showed a negative trend between ME and RE values for each standard at both concentrations, indicating that lots with higher recovery also had higher matrix effects, and vice versa ( Figure S3 ).

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Set 1 showed a negative association between the peak areas and those of the IS at 50 nM, and a positive trend at 100 nM.

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