The Mechanisms of Imatinib Resistance in Gastrointestinal Stromal Tumours: Theoretical Basis and Therapeutic Aspect.

J Cell Mol Med · 2025 · PMC12613292 · PMID 41230918

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This combination therapy showed a trend of superior efficacy in the imatinib‐sensitive group [ 81 ]. mTOR is central in regulating cell growth and proliferation, and it plays a key role in angiogenesis [ 82 ].

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