Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.

Front Endocrinol (Lausanne) · 2025 · PMC12615161 · PMID 41244054

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0.0800

closest p · 1.6× alpha

0.0800

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did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

Decreases in the uterine and ovarian organ coefficients were observed in the FTO+/- mice at 4 weeks, but these decreases did not reach statistical significance ( p = 0.08) ( Figure 6E ).

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