Total alkaloids from <i>Coptis chinensis</i> Franch ameliorate hyperlipidemia and hepatic steatosis via dual pathway modulation of AMPK/SREBP-1c and PPARα/LXRα in mice.

Front Pharmacol · 2025 · PMC12615409 · PMID 41244823

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a clear trendno p-value reported

Key metrics such as body weight reduction, improvement in serum lipid profiles (TC, TG, LDL-C), and normalization of lipid metabolism gene expression (e.g., HMGCR, SREBP-1c, LPL) exhibited a clear trend of enhanced efficacy with increasing TAC concentration.

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Total alkaloids from &lt;i&gt;Coptis chinensis&lt;/i&gt; Franch ameliorate hyperlipidemia and hepatic steatosis via dual pathway modulation of AMPK/SREBP-1c and PPARα/LXRα in mice.

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Total alkaloids from <i>Coptis chinensis</i> Franch ameliorate hyperlipidemia and hepatic steatosis via dual pathway modulation of AMPK/SREBP-1c and PPARα/LXRα in mice.