Innovative aptamer approaches in glial tumor diagnostics and therapy: Progress and future directions.

The TIM-3 aptamer by itself enhanced T cell infiltration in the tumor and showed a trend of prolonged survival in mice; when combined with radiation therapy, it significantly increased median survival and produced some long-term survivors, an effect lost if T cells were depleted. 37 This indicates aptamers can function as immunotherapeutic agents, either alone or as adjuvants to standard treatments like radiotherapy.

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