Association between S-ketamine induced changes in glutamate levels in the pregenual anterior cingulate cortex and plasma brain-derived neurotrophic factor in healthy subjects.

Spearman correlation analyses showed a trend-level positive correlation (rs = 0.34, p = 0.088, adjusted α = 0.0335) in the S-ketamine condition ( Figure 1A ; n = 26), whereas a non-significant negative correlation was detected (rs = -0.29, p = 0.2138, adjusted α = 0.025) in the placebo condition ( Figure 1B ; n = 20).

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