Histamine plasma levels from dietary histidine/histamine intake correlate with CGRP in trigeminal tissues.

However, there are significant differences ( p < 0.05) in the CGRP plasma levels between the control groups, CGRP concentrations in ileum between the high-histamine groups and highly significant differences ( p < 0.0005) in neural tissues between Altromin and Ssniff fed mice.

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Notably, supplementation with 3 g/kg of histamine in the Altromin diet for 22–32 days resulted in a significant increase in plasma histamine, whereas a 3-day exposure, although showing a trend, did not reach statistical significance.

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