Early Oxygenation and Mortality in Infants Treated with Inhaled Nitric Oxide (iNO) for Persistent Pulmonary Hypertension of the Newborn (PPHN).

Figure 4 , A, confirmed a statistically significant association between maximum Pa o 2 and death (Wald χ 2 = 8.72, df = 3, P = .033) and borderline significant nonlinearity (Wald χ 2 = 5.81, df = 2, P = .05).

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Interestingly, the mean Fi o 2 over the first 12 postnatal hours was lower in the hypoxemia group and greater in the severe hyperoxemia group compared with the normoxemia group, although this difference did not reach statistical significance.

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