Neural, psychological, and daily life evidence for a transdiagnostic process of affective dysregulation in depression and chronic widespread pain.

After false discovery rate correction for performing 6 tests (for momentary valence, calmness, anxiety, rumination, stress, and energetic arousal) in total, all results remain marginally significant at P = 0.063.

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For the regulate > view contrast, both patients with MDD and HC showed a trend toward higher amygdala activation compared to patients with FMS (T = 3.00, P FWE = 0.055 and T = 2.78, P FWE = 0.093, respectively, all P -values FWE-corrected for voxels in the bilateral amygdala using the AAL3 atlas). 71 No other group comparisons revealed any differences, and we found no evidence that any group exhibited higher amygdala activation during regulate compared to view at baseline.

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