Sex-dependent modulation of PCB-mediated toxicity from a proteomic and microbiome perspective.

Sci Rep · 2025 · PMC12618472 · PMID 41238692

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0540

boldest claim

The sentences

a trend towards significancep =0.051so close (0.05 < p ≤ 0.1)

Exposed females also exhibited a trend towards significance for higher FMO3 expression vs. their sex-matched controls ( p =0.051), potentially reaffirming the proteomic findings wherein the MPCB vs.

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showed a trendp =0.054so close (0.05 < p ≤ 0.1)

Nonetheless, exposed females also showed a trend towards significance for increased CD36 protein expression levels ( p =0.054), compared to their sex-matched controls.

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a nonsignificant trendno p-value reported

Although the current study did not record a significant decrease in estradiol (E2) circulatory levels in the PCB-exposed group, a nonsignificant trend was observed 16 .

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