Topical losartan for established corneal fibrosis with machine learning-based predictors.

Ther Adv Ophthalmol · 2025 · PMC12618809 · PMID 41245430

Europe PMC DOI

hedged sentences

0.0518

closest p · 1.0× alpha

0.0550

boldest claim

The sentences

nearing significancep = 0.0518so close (0.05 < p ≤ 0.1)

Lastly, total corneal densitometry, excluding the 10–12 mm zone, decreased from 31.19 ± 6.68 GSU to 28.98 ± 5.18 GSU, with ANOVA nearing significance ( p = 0.0518) and post-hoc analysis confirming significance ( p = 0.0342).

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a decreasing trendp = 0.0531so close (0.05 < p ≤ 0.1)

Anterior densitometry declined from 38.78 ± 10.31 GSU to 34.72 ± 9.49 GSU, with ANOVA showing significance ( p = 0.0222), though post-hoc comparison showed only a decreasing trend ( p = 0.0531).

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trending toward significancep = 0.055so close (0.05 < p ≤ 0.1)

Posterior densitometry decreased from 18.33 ± 5.82 GSU to 16.32 ± 4.62 GSU, trending toward significance ( p = 0.055), but post-hoc analysis confirmed a significant reduction ( p = 0.0414).

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showed a trendno p-value reported

While longer leukoma duration showed a trend toward improved vision, it was not statistically significant, suggesting chronicity alone does not determine treatment response.

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