Effectiveness of gabapentinoids in orthopedic surgeries: a systematic review and meta-analysis of postoperative pain, and opioid-sparing effects.

BMC Anesthesiol · 2025 · PMC12619272 · PMID 41239206

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did not reach statistical significanceno p-value reported

At 12 hours post-surgery, the pooled WMD of −0.18 (95% CI: −0.83, 0.46) did not reach statistical significance, suggesting that gabapentinoids may not be as effective in the immediate postoperative period.

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