Real-world Canadian data on belumosudil therapy in heavily pretreated patients with steroid-refractory chronic graft-versus-host disease: treatment outcomes and risk factor analysis for failure-free survival.

Risk factor analysis for failure-free survival following belumosudil treatment When analyzing the risk factors for BEL failure, the univariate analysis identified the following risk associated with FFS following BEL treatment: (1) cGvHD involvement in more than four organs (HR 10.07, [1.69 − 60.08], p = 0.011) was linked to worse FFS; (2) previous episode of aGvHD (HR 7.58, [0.87–65.57], p = 0.066) suggested a trend towards worse FFS; (3) the presence of fibrotic component of cGvHD (HR 0.13, [0.02–1.00], p = 0.051) showed a trend towards a better FFS (Table 3 ).

also in 53,322 other papers