Circulating free DNA as a predictive biomarker for response to nivolumab and platinum-based chemotherapy in metastatic esophageal adenocarcinoma: a prospective pilot study.

Front Oncol · 2025 · PMC12620205 · PMID 41256319

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.1800

boldest claim

The sentences

a trend toward significancep = 0.07so close (0.05 < p ≤ 0.1)

showed a trendp = 0.07so close (0.05 < p ≤ 0.1)

The cfDNA D30 ratio <0.4 showed a trend toward significance (adjusted OR 1.9, 95% CI 0.95–3.8, p = 0.07).

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a positive trendp = 0.18not close (p > 0.1)

did not reach statistical significancep = 0.18not close (p > 0.1)

Although PD-L1 CPS ≥5% showed a positive trend toward response, the association did not reach statistical significance (adjusted OR: 1.4; p = 0.18).

also in 6,774 other papers

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