Interestingly, arsenic trioxide (ATO), a standard therapy for APL when combined with ATRA, showed a trend toward increased sensitivity in NB4- MALNC KO cells in the DSRT screen (sDSS = 1.633).
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MALNC: a new mutant NPM1/IDH2<sup>R140</sup> and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response.
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