Impact of total motile sperm count on ICSI outcomes in male factor infertility: A retrospective cohort study.

Medicine (Baltimore) · 2025 · PMC12622741 · PMID 41239584

Europe PMC DOI

hedged sentences

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

borderline significanceP = .063so close (0.05 < p ≤ 0.1)

Logistic regression identified fertilization rate as an independent predictor of clinical pregnancy (odds ratio = 1.020; 95% confidence interval: 1.008–1.032; P = .001), while day 3 embryo score showed borderline significance ( P = .063).

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marginally significantP = .063so close (0.05 < p ≤ 0.1)

The day 3 embryo score demonstrated a marginally significant association ( B = 0.275; P = .063; OR = 1.316; 95% CI: 0.986–1.758), suggesting a potential link that warrants further investigation (Table 5 ).

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a positive trendno p-value reported

[ 32 , 33 ] We also observed that pregnancy rates followed a positive trend with increasing TMSC, with the highest outcomes occurring in the groups with higher motile sperm counts.

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did not reach statistical significanceno p-value reported

While TMSC did not reach statistical significance as an independent predictor in multivariate models, it showed a marginal association with fertilization success and demonstrated modest predictive value in ROC analysis.

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