Chronotherapy With Once-Daily Osilodrostat Improves Cortisol Rhythm, Quality of Life, and Sleep in Cushing's Syndrome.

J Clin Endocrinol Metab · 2025 · PMC12623021 · PMID 40172910

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0690

boldest claim

The sentences

borderline significantP = .050actually significant

Specifically, cortisol AUC 16:00-08:00 significantly decreased with T OD2 compared to T BID (20.2 [15.0-35.5] ng/mL/h at T BID vs 19.3 [11.8-24.0] ng/mL/h at T OD2 , P = .036), while cortisol AUC 16:00-04:00 showed a borderline significant reduction (13.1 [8.5-25.4] ng/mL/h at T BID vs 12.2 [8.7-14.0] ng/mL/h at T OD2 , P = .050).

also in 6,883 other papers

showed a trendP = .069so close (0.05 < p ≤ 0.1)

The nadir time at T OD showed a trend toward delay, more evident for cortisone (from 20:10 [15:06-01:13] to 00:14 [21:10-03:18], P = .069).

also in 33,237 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.