Mesenchymal stem cells added to second-line therapy improve response and failure-free survival in steroid-refractory acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: A meta-analysis of randomized controlled trials.

Front Oncol · 2025 · PMC12623177 · PMID 41262904

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showed a trendP = 0.063so close (0.05 < p ≤ 0.1)

Furthermore, MSC administration derived from BM was associated with a significant improvement in OR (RR: 1.14, 95% CI: 1.00-1.30, P = 0.047), whereas those from UC showed a trend without reaching statistical significance (RR: 1.12, 95% CI: 0.99-1.25, P = 0.063) ( Figure 3E ). 3.4 Chronic GVHD, failure-free survival, and overall survival Two studies provided HR data for chronic GVHD.

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