Although IMP3 did not reach statistical significance in the survival analysis, it showed associations with several adverse prognostic features such as lymph node metastases, high grade, and p53-mutated profile, whose negative prognostic role in pSCC has been well documented 9 , 39 – 44 , together with the role of p53 in epithelial-mesenchymal transition 45 and its association with tumor budding 46 , both p53 and tumor budding being strong negative prognostic markers 9 .
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