Subtyping schizophrenia via machine learning by using structural neuroimaging.

[ 8 ], using global meta- and mega-analyses in a large international sample, observed that deficit schizophrenia (DSZ) patients exhibited more pronounced cortical thinning than non-deficit schizophrenia (NDSZ) patients—particularly in the right frontoparietal cortex—with small but consistent effect sizes (Cohen’s d ≈ –0.13 to –0.20) in key regions such as the right inferior parietal lobule, caudal middle frontal gyrus, and superior frontal gyrus, although these differences did not reach statistical significance.

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