A Comparative Effectiveness of Intravenous Fluids and Insulin Regimens in the Acute Management of Diabetic Ketoacidosis (DKA) and Hypoglycemia: A Systematic Review.

Cureus · 2025 · PMC12624376 · PMID 41262789

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showed a trendp = 0.002actually significant

Fluid therapy with Plasmalyte-148 showed a trend toward faster DKA resolution at 24 hours (69% vs. 36%; OR 4.24, 95% CI 1.68-10.72; p = 0.002) compared to sodium chloride, though the difference at 48 hours was not statistically significant [ 15 ].

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