Integrative multi-omics and Mendelian randomization identify WWOX and THBS2 as potential therapeutic targets in mature T/NK-cell lymphoma.

J Transl Med · 2025 · PMC12625014 · PMID 41254692

Europe PMC DOI

hedged sentence

0.1600

closest p · 3.2× alpha

0.1600

boldest claim

The sentences

did not reach statistical significanceP = 0.160not close (p > 0.1)

Additionally, the therapeutic target WWOX identified by eQTL-MR showed consistent significant causal association at the protein level (OR = 0.117, 95% confidence interval (CI): 0.024–0.559, P = 7.2E-03), but this association did not reach statistical significance after FDR correction (FDR-corrected P = 0.160).

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