Effects of supplementation with two probiotic strains (Lactobacillus helveticus and Bifidobacterium longum) on hormonal status, oxidative stress, and clinical symptoms in women with polycystic ovary syndrome: a randomized clinical trial.

Nutr J · 2025 · PMC12625425 · PMID 41254712

Europe PMC DOI

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0.0800

closest p · 1.6× alpha

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did not reach statistical significanceP = 0.08so close (0.05 < p ≤ 0.1)

Compared to the placebo, the intervention group revealed a reduction in testosterone total levels following probiotic supplementation ( P = 0.03), however the between-group difference did not reach statistical significance after adjustment for baseline values and other potential confounders (−3.37; 95% CI (−11.85, 5.11) vs. 6.48; 95% CI (3.43, 9.53) ng/dL, P = 0.08).

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a decreasing trendno p-value reported

Furthermore, testosterone total levels showed a decreasing trend in the intervention group, although the between-group changes were not statistically significant after baseline value and other confounders adjustment (-3.37; 95% CI (-11.85, 5.11) vs. 6.48; 95% CI (3.43, 9.53) ng/dL, P = 0.08).

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