ADAMTS-1, ADAMTS-5 and ADAMTS-13 are considered potential targets in the treatment of frozen shoulder.

Although the p -values from the MR-Egger, simple mode, and weighted mode methods did not reach statistical significance (all P > 0.05), the direction of the DrugOR estimates remained consistent with the primary analysis (DrugOR < 1), indicating that all analytical approaches support a potential therapeutic effect of reducing ADAMTS-5 levels on FS.

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