A bispecific antibody targeting PD-L1/TNFR2 increases tumor targeting and enhances antitumor efficacy in colorectal cancer.

J Immunother Cancer · 2025 · PMC12625873 · PMID 41238220

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did not reach statistical significanceno p-value reported

While ATAPL1-treated mice exhibited a modest increase in inflammatory cytokines compared with untreated controls, and this elevation did not reach statistical significance, suggesting minimal systemic immune activation ( online supplemental figure S3B ).

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