Barely Significant
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Association of TNF-α polymorphisms rs1800629 (-308G>A) and rs361525 (-238G>A) with type 2 diabetes mellitus in the Punjabi population of Pakistan.

Front Endocrinol (Lausanne) · 2025 · PMC12626861 · PMID 41268160

Europe PMCDOI
3
hedged sentences
0.0640
closest p · 1.3× alpha
0.0640
boldest claim

The sentences

did not reach statistical significancep = 0.064so close (0.05 < p ≤ 0.1)
Although genotype-level differences did not reach statistical significance (p = 0.064–0.512), allele frequency analysis showed that the A allele was more common among cases (5.26%) than controls (0.53%), with the G allele being more frequent in the control group.

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an increasing trendno p-value reported
Our results demonstrate that the minor A alleles of both polymorphisms were significantly enriched in T2DM patients compared with healthy controls, and these alleles also showed an increasing trend with FBS, which may reach statistical significance in larger patient cohorts.

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a positive trendno p-value reported
The A alleles of TNF-α promoter polymorphisms rs1800629 and rs361525 were significantly more frequent in T2DM cases and showed a positive trend with higher fasting glucose, suggesting increased susceptibility to T2DM that may be confirmed in larger cohorts.

also in 11,005 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.