We regarded a locus as being fully replicated if the locus from the original GWAS study (defined as the genomic risk locus ± 100 kb) overlapped with a genomic risk locus in any of the latent factors ( P GWAS < 5 × 10 −8 ) or partially replicated if it demonstrated a nominally significant association with one of the latent factors ( P Bonferroni < 0.001 (that is, 0.05/47)).
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Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling.
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