Prophylactic Rectal ESD (Endoscopic Submucosal Dissection) Defect Closure and Post-ESD Clinical Outcomes: An International Multi-Center Study (with Video).

Dig Dis Sci · 2025 · PMC12627156 · PMID 40553399

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did not reach statistical significanceno p-value reported

Prophylactic closure of rectal ESD defects had a trend towards less DAE in these high-risk groups including no delayed perforations and a 29% risk reduction in NICE 3 lesions when defects were closed, but these differences did not reach statistical significance.

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