Monocyte inflammation and resilience to Alzheimer's disease: novel genetic risk genes identified by transcriptome-wide association study.

Transl Psychiatry · 2025 · PMC12627486 · PMID 41253753

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did not reach statistical significanceno p-value reported

Although activated monocytes exhibited a trend toward higher abundance in AD, the difference did not reach statistical significance (Fig. 6d , FDR = 0.0669).

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an overall trendno p-value reported

We tested a range of LD-pruning thresholds, from 0.20 to 0.95, and found that there was an overall trend of deflating TWAS test statistics when adding more, correlated SNPs.

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