LRRK2 p.G2385R and p.R1628P variants in a multi-ethnic Asian Parkinson's Cohort: epidemiology and clinical insights.

NPJ Parkinsons Dis · 2025 · PMC12627830 · PMID 41253790

Europe PMC DOI

hedged sentence

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

did not reach statistical significancep = 0.063so close (0.05 < p ≤ 0.1)

When combining the p.R1628P, p.G2385R, and double heterozygous p.R1628P(;)G2385R variant carriers into a single group, variant carriers appeared less likely to have dementia (5.6%, 5/90) compared to non-carriers (16.3%, 8/49), although the difference did not reach statistical significance (p = 0.063).

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