Cholinergic basal forebrain atrophy accelerates cognitive decline via cortical thinning: The moderating role of amyloid-β pathology in preclinical Alzheimer's disease.

J Prev Alzheimers Dis · 2025 · PMC12627883 · PMID 40731233

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0.4200

closest p · 8.4× alpha

0.4200

boldest claim

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did not reach statistical significanceP = 0.42not close (p > 0.1)

While PACC5 scores were marginally lower in the Aβ+ group (mean = −0.0018, SD = 0.590) than in the Aβ− group, this difference did not reach statistical significance ( P = 0.42).

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