BTK inhibitor ibrutinib reduces LPS-induced inflammation in C8-B4 microglia.

EXCLI J · 2025 · PMC12627995 · PMID 41268328

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did not reach statistical significanceno p-value reported

Ibrutinib inhibits the upregulation of LPS-induced inflammatory markers in C8-B4 cells Stimulation of C8-B4 microglial cells with LPS led to an upward trend in the expression of pro-inflammatory markers CD86 and TNF-α; however, these increases did not reach statistical significance when compared to the control group (Figure 9 (Fig. 9) ).

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