Low-dose radiotherapy combined with chemoimmunotherapy yields superior survival outcomes compared with chemoimmunotherapy alone for patients with small cell lung cancer with liver metastasis: a retrospective study.

Subgroup analyses of OS revealed that the HR for the thoracic radiotherapy subgroup was marginally significant (HR 0.47, 95% CI 0.22–1.02, p = 0.056), and the HR for the later-line treatment subgroup was also marginally significant (HR 0.43, 95% CI 0.18–1.01, p = 0.053).

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Notably, for SCLC patients with LM, a subgroup historically associated with limited treatment efficacy, even a modest extension in PFS may translate to meaningful symptom alleviation and could potentially signal a favorable trend in OS.

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Although the difference in OS did not reach statistical significance, However, we argue that it is critical to explore the underlying factors.

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