Influence of Potential Pharmacodynamic Drug Interactions in Pharmacotherapy of Coronary Heart Disease with Comorbid Conditions on Treatment Adherence: A Cross-Sectional Study of a Ukrainian Patient Cohort.

Patient Prefer Adherence · 2025 · PMC12630006 · PMID 41280284

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highly significantno p-value reported

The coefficients for “pharmacodynamic antagonism” and “drug toxicity” in this study are statistically highly significant factors that negatively affect treatment adherence.

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a clear trendno p-value reported

This result suggests a clear trend: as the number of pDDIs increases, the risk of toxic effects on the body also rises.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.