Changes in the "U-Shaped" Distribution of Airway Hyperresponsiveness and Characterization of Inflammatory Phenotypes in Different Age Groups.

The pairwise comparison revealed that there was no significant difference between the adolescent group and the youth group (P = 0.711), the youth group > the middle-aged group (P < 0.04), and the middle-aged group > the old-aged group (P = 0.005); neutrophils H(3) = 16.854, p < 0.001, the difference between the four groups was statistically significant, pairwise comparisons revealed that the adolescent group <youth group (P=0.006), no significant difference between the youth group and middle-aged group (P=0.844), and the middle-aged group <elderly group (P=0.050) was borderline significant; monocyte H(3) =17.489, P<0.001, the difference between the four groups was statistically significant, and pairwise comparisons revealed that the elderly group >middle-aged group (P<0.001), the elderly group > the youth group (P = 0.017), the adolescent group > the middle-aged group (P = 0.005).

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Whereas the neutrophils increased year by year with the change of the age stage, and the monocytes showed a trend of decreasing and then increasing.

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