Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury.

These findings align with our CyTOF analysis, which identified a CD88+ (C5aR1+) microglial cluster that was more abundant in CR2-Crry-treated animals, although it did not reach statistical significance, likely due to signal dilution from analyzing whole brain tissue, whereas the relevant population was primarily localized to the hippocampus.

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