Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling.

Nat Commun · 2025 · PMC12630879 · PMID 41261166

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did not reach statistical significanceno p-value reported

Generally, αPD-L2 enhanced host IL-17-dependent per-cell IFNγ production in total CD45 + immune cells, CD8 + , and CD4 + T cells in aged, but not young WT, but did not reach statistical significance (Fig. 3e–g ).

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