Migration of CD8 + TSCM cells into intestine via PPBP-CXCR2 axis increases host stress susceptibility by inhibiting gut microbiome-derived homovanillic acid.

Nat Commun · 2025 · PMC12630981 · PMID 41258106

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did not reach statistical significanceno p-value reported

5D–F , in Rag1 −/− mice receiving pathological CD8 + T SCM cells, SB265610 treatment promoted an increase of HVA levels in the microbiota, although this increase did not reach statistical significance; however, it significantly elevated HVA concentrations in both brain and plasma.

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