Not One Method to Rule Them All: A Comparative Study of Chromatographic Platforms (RP-LC-, HILIC-, SFC-, and IC-HRMS) for Water Analysis.

Anal Chem · 2025 · PMC12631722 · PMID 41198048

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a clear trendno p-value reported

Analysis of the log D pH7.4 distribution of detected compounds demonstrated a clear trend in median polarity between platforms: IC (∼−1.5 to −1) < HILIC (∼0 – 0.2) < SFC (∼1.5 – 2.4) < RP-LC (∼2.6 – 3.2).

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