Ninjurin-1 drives atherosclerosis progression via <i>NF-κB/CXCL-8</i> activation in endothelial cells.

Front Immunol · 2025 · PMC12634354 · PMID 41280941

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a decreasing trendp>0.05actually significant

RT-qPCR analysis revealed that CXCL-8 mRNA expression was significantly downregulated in Ninj1-silenced HUVECs compared to control cells (p=0.016), while TNFAIP3 and CXCL-1 mRNA levels showed a decreasing trend without statistical significance (p>0.05) ( Figures 4A–C ).

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did not reach statistical significanceno p-value reported

As shown in Figures 4M–O , mPN12 treatment markedly decreased Cxcl2 expression, whereas Cxcl1 displayed a downward trend that did not reach statistical significance, and Tnfaip3 expression remained unchanged.

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