Safety and adverse events associated with dexmedetomidine for sedation in adult ICU patients: a systematic review and meta-analysis.

Front Med (Lausanne) · 2025 · PMC12634627 · PMID 41281993

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did not reach statistical significanceno p-value reported

Although some smaller studies did not reach statistical significance due to wide confidence intervals (e.g., Huang Z 2012: OR = 13.95, 95% CI [0.75, 259.34]) ( 23 ), the overall consistent direction of effect across all studies strongly suggests that dexmedetomidine use is associated with elevated bradycardia risk.

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