Buprenorphine Substitution as a Tapering Strategy for Opioid Discontinuation in Patients with Chronic Pain: A Nonrandomized and Proof of Concept Study.

Pain Ther · 2025 · PMC12634938 · PMID 41042438

Europe PMC DOI

hedged sentence

0.0760

closest p · 1.5× alpha

0.0760

boldest claim

The sentences

did not reach statistical significancep = 0.076so close (0.05 < p ≤ 0.1)

Logistic regression yielded an odds ratio (OR) of 4.08 [0.90–21.23], suggesting a higher likelihood of success with buprenorphine, although the difference did not reach statistical significance ( p = 0.076, Table 2 ).

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